[Stem Cell Research & Therapy] Researchers developed a method to isolate and culture hair follicle-derived melanocytes. They identified melanocytes at the cellular, protein, and gene levels and established a mouse model of vitiligo using the melanoma/T regulatory cell exhaustion induction method.

[Nature Cancer] Scientists found that tRNA N1-methyladenosine (m¹A) methyltransferase TRMT6 is upregulated in human CRC tissues and high TRMT6 expression correlates with poor survival in patients with CRC.

[Free Radical Research] Dioscin, a compound extracted from the Paris polyphylla rhizomes roots, induced ferroptosis through SLC7A11/GPX4 axis, and was involved in the regulation of inhibiting metastasis of gastric cancer.

[Functional & Integrative Genomics] With findings in bioinformatic analysis, researchers further validated the involvement of leucine rich repeats protein 1 (LRR1) in HCC progression by cellular experiments. The expression of LRR1 is significantly upregulated in HCC compared to normal liver tissues and cell line.

[Cellular & Molecular Immunology] The authors discuss the major populations of macrophages resident in the liver, their location, functions, development, and role in maintaining the liver in the face of injury and infection.

[Stem Cell Research & Therapy] Scientists investigate the effect of protein arginine methyltransferase 1 (PRMT1 ) on MSC function and therapeutic efficacy using a mouse myocardial infarction model.

[Hepatology Communications] Scientists optimized the differentiation protocol by addition of a combination of small molecules to inhibit epithelial–mesenchymal transition in iPSC-derived hepaticytes, and further characterized their function both in vitro and in vivo analyses.

[Cell Communication and Signaling] Breast cancer cell kinome activity profiling suggested matrix stiffness-upregulation of 53 kinases, among which 16 kinases were also regulated by integrin β1.

[Science Translational Medicine] The authors identified cadherin-17 (CDH17) as a candidate antigen for CAR T cell therapy of colorectal cancer (CRC) liver metastases. When used in a CRC liver xenograft model, CDH17 CAR T cells efficiently suppress tumor growth upon either systemic or locoregional administration.

[ACS Nano] Scientists employed a strategy using nanostructures with controlled chirality to precisely assess the impact of molecular and supramolecular chirality on mesenchymal stem cell (MSC) osteogenic differentiation.

[New England Journal of Medicine] This trial showed significantly longer progression-free survival and overall survival with first-line treatment with EC+mFOLFOX6 than with standard care among patients with BRAF V600E–mutated metastatic colorectal cancer.

[Nature] Scientists identified the chromatin-remodelling enzyme ATRX as a key regulator of colonic lineage fidelity and metastasis in colorectal cancer.